We are fortunate enough to work with many start ups founded by entrepreneurs in the travel industry. I agree with Jos's article having set up my own business a decade ago,  Starting a company is a riveting roller coaster of emotions with tremendous highs and at times, difficult lows.  My advice would be to constantly challenge your assumptions, innovate new ideas and business processes, and to surround yourself with smarter people than yourself.   Regularly assess your brand proposition as your company may look very different six months or a year from now.  Just don't stop evolving, and enjoy the journey.  Oh and do take a holiday!